Dr. Vipin Madhavan

Senior Postdoctoral Fellow
 
Academic Profile
Doctoral Degree:Griffith University, Australia
Post Graduation:MS University of Leicester, UK
Email:vipinm@biochem.iisc.ernet.in, tpvipin@gmail.com
Project Title:Biochemical characterization of proteins involved in yeast synaptonemal complex.
Abstract

Meiosis is a specialized type of sexual reproduction which results in formation of four haploid gametes from diploid cells. Unlike mitosis, in meiosis two rounds of chromosome segregation follow a single round of DNA replication because of which the chromosome number is reduced to half. In meiotic recombination, the paternal and the maternal chromosomes exchange segments of DNA giving rise to recombinant molecule that contains information from both, paternal and maternal chromosomes resulting in generation of genetic diversity.

In sexually reproduction organism’s meiotic recombination takes place in the context of a meiosis specific, tripartite protinaceous structure -‘Synaptonemal complex’. Mutants that are defective in SC formation eventually show defects in meiotic recombination such as chromosome mis-segragation.

We aim to understand the role of synaptonemal complex proteins in chromosome synapsis, chromosome segregation.

Publications
  • Daniel Stones, Alexander Fehr, Laurel Thompson, Jacqueline Rocha, Nicolas Perez- Soto, T P Vipin Madhavan, Kerstin Voelz, and Anne-Marie Krachler(2017). Zebrafish (Danio rerio) as a vertebrate model host to study colonization, pathogenesis and transmission of food-borne Escherichia coli O157. mSphere. pii: e00365-17. | Pubmed
  • T.P.VipinMadhavan, James D. Riches, Martin J. Scanlon, Glen C. Ulett, Harry Sakellaris(2016). Binding of CFA/I Pili of Enterotoxigenic Escherichia coli to Asialo-GM1 is mediated by the minor Pilin,CfaE. Infection and Immunity.2016 Apr 22; 84 (5) : 1642-9. | Pubmed
  • T.P.VipinMadhavanand & Harry Sakellaris(2015). Colonization Factors of Enterotoxigenic Escherichia coli. Advances in applied microbiology. 2015;90c:155-97. Epub 2015/01/18. | Pubmed
  • T.P.VipinMadhavan, Jason. A. Steen, Philip Hugenholtz and Harry Sakellaris(2014). Genome sequence of Enterotoxigenic E. coli (ETEC) strain 06:H16: CFA/II strain B2C. Genome Announcements. 2(2):e00247-14. | Pubmed
  • Krishnendu Khan, T. P. Vipin Madhavan, RuchaKshirasagar, Kannan N. Boosi, Parag Sadhale and K. Muniyappa (2013). The N-terminal disordered domain of Saccharomyces cerevisiae Hop1 Protein is dispensable for DNA Binding, bridging as well as for synapsis of Double-stranded DNA Molecules but it is Necessary for Spore Formation. Biochemistry, 2013 Aug 6; 52(31):5265-79 | Pubmed
  • Krishnendu Khan, T.P. Vipin Madhavan, K. Muniyappa(2010). Cloning, overexpression and purification of functionally active Saccharomyces cerevisiae Hop1 protein from Escherichia coli, Protein Expression and Purification, vol.72, no.1, pp 42-47 | Pubmed