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P.Sanjeev

PhD Student
 
Academic Profile
Post Graduation:Indian Agricultural Research Institute, New Delhi.
Graduation:Acharya N.G. Ranga Agricultural University, Hyderabad.
Email:sanjeev.psv@biochem.iisc.ernet.in
Project Title:Studies on the role of MRN complex in genome stability using cultured mammalian cells.
Abstract

Fanconi anemia (FA) is an autosomal recessive and X-linked genetic disorder characterized by congenital abnormalities, progressive bone marrow failure and pronounced cancer susceptibility. The FA-BRCA DNA damage response network is comprised of fifteen bonafide disease linked proteins, as well as numerous non FA proteins, that function cooperatively in DNA (ICL) repair.

The hallmark of FA patient cells, as well as BRCA1/2- deficient cells, is hypersensitivity to the clastogenic effects of DNA cross- linking agents such as mitomycin C and cisplatin. Our research is aimed at elucidating the role of HR pathway components in FA cells.

Publications
  • Sanjeev, P., Chaudhary, D.P., Sreevastava, P., Saha, S., Rajenderan, A., Sekhar, J.C., and Chikkappa, G.K. (2014). Comparison of Fatty Acid Profile of Specialty Maize to Normal Maize. J Am Oil Chem Soc 91, 1001-1005.| Web of Science (TS)