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Manoj Thakur

PhD Student
 
Academic Profile
Post Graduation:M.Sc School of Life Sciences, JNU
Graduation:B.Sc Acharya Narendra Dev College, University of Delhi.
Email:mthakur@biochem.iisc.ernet.in
Project Title: Functional characterization of UvrABC complex.
Abstract

Tuberculosis, caused by Mycobacterium tuberculosis, causes about two million deaths annually. During infection, the M. tuberculosis resides within the host macrophages, where they are likely to encounter reactive nitrogen and oxygen species that are capable of damaging its genome. So, the ability of the pathogen to safeguard its genome integrity is of paramount significance for its survival within the host. For its successful endurance within the host, this pathogen must need a robust DNA repair mechanism. Genome sequence analysis of M. tuberculosis revealed that it lacks mismatch repair pathway suggesting a greater role for other DNA repair pathways, the nucleotide excision repair (NER) pathway amongst these.

Publications
  • Thakur, M., Kumar, M.B., and Muniyappa, K. (2016) Mycobacterium tuberculosis UvrB Is a Robust DNA-Stimulated ATPase That Also Possesses Structure-Specific ATP-Dependent DNA Helicase Activity. Biochemistry 55, 5865–5883| Pubmed